Simparica Trio for Dogs | Monthly Flea, Tick & Heartworm Protection

Simparica Trio (sarolaner, moxidectin, and pyrantel chewable tablets) is a monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds, Simparica Trio begins working against fleas in just four hours and kills five types of ticks - including the deer tick that may cause Lyme disease. Just one tasty liver-flavored chew does the job of two or three parasite medications, and in a study nine out of 10 dogs ate Simparica Trio voluntarily.¹ It can be given with or without food. Simparica Trio comes with a 100% satisfaction guarantee on protection. If you feel that Simparica Trio isn’t providing sufficient protection, please call Zoetis’ medical support team to discuss the satisfaction guarantee at 1-888-ZOETIS1. Trust the #1 heartworm disease preventative chosen by veterinarians² and prescribed to over 7 million patients.³ Available by veterinarian prescription only. Ask your vet if Simparica Trio is right for your dog. References: 1. Study A161C-US-15-634. Data on file. Zoetis Inc. 2. Heartworm Disease Preventative; DVM 360 ’22 Survey. 3. Kynetec Purchasing Data Vet Clinics Q3 QBR IMPORTANT SAFETY INFORMATION: Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See Prescribing Information at SimparicaTrioPI.com.

• One Chew, Triple Protection: Simparica Trio is the first FDA-approved monthly chewable that protects your dog against heartworm disease, ticks, fleas, roundworms, and hookworms. Approved for puppies as young as eight weeks old and weighing at least 2.8 pounds.
• Heartworm Protection: Studies to support FDA-approval showed one dose provided 100% protection against heartworm disease.
• Prevent Lyme Infections: Simparica Trio is the first FDA-approved product of its kind and the only one approved to prevent Lyme infections as a direct result of killing deer ticks. It’s proven to kill five types of ticks including the Gulf Coast Tick, Deer Tick, American Dog Tick, Lone Star Tick, Brown Dog Tick.
• Kills Fleas & Intestinal Parasites: Prevents flea infestation by killing fleas before they can even lay eggs. Starts killing within 4 hours and achieved 100% effectiveness in 8 hours in a study. Treats roundworms and hookworms to protect your dog from intestinal parasites.
• Satisfaction Guaranteed & Easy-to-Administer: Simparica Trio comes with a 100% satisfaction guarantee on prevention and is administered once a month with or without food. In a study 9 out of 10 dogs voluntarily consumed this tasty liver-flavored chew.¹

Frequently Asked Questions About Simparica Trio for Dogs

What is Simparica Trio for Dogs?

Simparica Trio for Dogs is a prescription, once-monthly chewable medication containing sarolaner, moxidectin, and pyrantel. It provides protection against heartworm disease, treats and controls certain intestinal worms, and kills fleas and several species of ticks.

What parasites does Simparica Trio protect against?

Simparica Trio helps prevent heartworm disease, kills fleas, treats and controls roundworms and hookworms, and controls several tick species, including deer ticks, American dog ticks, brown dog ticks, lone star ticks, and Gulf Coast ticks. It is also approved to prevent Lyme disease infections resulting from killing deer ticks.

How old must a puppy be to take Simparica Trio?

Simparica Trio is approved for dogs and puppies eight weeks of age or older weighing at least 2.8 pounds. Your veterinarian will determine the appropriate chewable tablet strength based on your dog's current weight.

How often should Simparica Trio be given?

Simparica Trio is administered once a month. It can be given with or without food. Follow your veterinarian's prescription and the official product label for dosing instructions.

How quickly does Simparica Trio start killing fleas?

According to the manufacturer, Simparica Trio starts killing fleas within four hours of administration. Its monthly flea control helps prevent infestations by killing fleas before they can lay eggs.

Does Simparica Trio require a veterinarian's prescription?

Yes. Simparica Trio is available by veterinary prescription only. Your veterinarian can evaluate your dog's health, heartworm testing needs, and parasite risks before prescribing the medication.

What side effects should I know about before giving Simparica Trio?

Vomiting and diarrhea were among the most frequently reported adverse reactions in clinical trials. Simparica Trio contains sarolaner, an isoxazoline medication associated with neurologic adverse reactions, including tremors, loss of coordination, and seizures. Tell your veterinarian if your dog has a history of seizures or other neurologic disorders.

Is Simparica Trio safe for pregnant or nursing dogs?

The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. Consult your veterinarian before use. Always follow the official prescribing information and your veterinarian's recommendations.